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Molecular Imaging with Spins: A Marriage of Quantum Mechanics with Machine Learning to Achieve High Resolution
Since its invention in the early 1970s, magnetic resonance imaging (MRI) has become a premier tool for structural imaging and functional imaging using water proton spin signals. MR spectroscopic imaging (MRSI) has also long been recognized as a potentially powerful tool for noninvasive molecular imaging by exploiting the spin signals from other molecules. However, state-of-the-art MRSI methods, after more than four decades of development, still far short of providing adequate spatial resolution, speed, and signal-to-noise ratio useful for routine clinical applications.
The talk will discuss our recent “breakthroughs” in overcoming the longstanding technical barriers of MRSI-based molecular imaging using a new technology known as SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). SPICE uses a subspace mathematical framework to effectively integrate rapid scanning, sparse sampling, constrained image reconstruction, quantum simulation, and machine learning. Preliminary results show an unprecedented capability for simultaneous mapping of brain structures, function and metabolism using intrinsic spin signals from multiple molecules. In this talk, I’ll give an overview of SPICE and also show some “SPICY” experimental results we have obtained.
Zhi-Pei Liang received his Ph.D. degree in Biomedical Engineering from Case Western Reserve University in 1989. He subsequently joined the University of Illinois at Urbana-Champaign (UIUC) first as a postdoctoral fellow (supervised by the late Nobel Laureate Paul Lauterbur) and then as a faculty member in the Department of Electrical and Computer Engineering. Dr. Liang is currently the Franklin W. Woeltge Professor of Electrical and Computer Engineering; he also co-chairs the Integrative Imaging Theme in the Beckman Institute for Advanced Science and Technology. Dr. Liang’s research is in the general area of magnetic resonance imaging and spectroscopy, ranging from spin physics, signal processing, machine learning, to biomedical applications. Research from his group has received a number of recognitions, including the Sylvia Sorkin Greenfield Award (Medical Physics, 1990), Whitaker Biomedical Engineering Research Award (1991), NSF CAREER Award (1995), Henry Magnuski Scholar Award (UIUC, 1999), University Scholar Award (UIUC, 2001), Isidor I. Rabi Award (International Society of Magnetic Resonance in Medicine, 2009), IEEE-EMBC Best Paper Awards (2010, 2011), IEEE-ISBI Best Paper Award (2010, 2015), Otto Schmitt Award (International Federation for Medical and Biological Engineering, 2012), Technical Achievement Award (IEEE Engineering in Medicine and Biology Society, 2014), and Andrew Yang Research Award (UIUC, 2017). Dr. Liang was selected as the Paul C. Lauterbur Lecturer for the 2016 ISMRM meeting and as the Savio L. Woo Distinguished Lecturer for the 2017 WACBE World Congress on Bioengeering. He is a Fellow of the IEEE, the International Society for Magnetic Resonance in Medicine, the American Institute for Medical and Biological Engineering, and the International Academy of Medical and Biological Engineering. Dr. Liang served as President of the IEEE Engineering in Medicine and Biology Society from 2011-2012 and received its Distinguished Service Award in 2015. He was elected Chair-elect of the International Academy of Medical and Biological Engineering in 2021.
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